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Many physicians still doubted that there was a wide-spread connection between smoking and disease

Methods Aerosol generation A Single Cigarette Smoking Machine (SCSM-STEP, CH Technologies), was calibrated to a puffing regimen of 60 mL puff volume, 4 s puff duration and a 30 s inter-puff interval

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However, these products are not without risk, and some consider them controversial as they continue to fill the physical need without addressing the psychological and behavioral sides of a nicotine addiction